Recent clinical trends in Toll‐like receptor targeting therapeutics

MA Anwar, M Shah, J Kim, S Choi - Medicinal research reviews, 2019 - Wiley Online Library
Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Immunobiology of Toll‐like receptors: emerging trends

S Pandey, DK Agrawal - Immunology and Cell Biology, 2006 - Wiley Online Library
Toll‐like receptors (TLR), a family of evolutionarily conserved pathogen recognition
receptors, play pivotal role as primary sensors of invading pathogens. TLR identify …

Revolutionizing medicine with toll-like receptors: A path to strengthening cellular immunity

JA Malik, G Kaur, JN Agrewala - International Journal of Biological …, 2023 - Elsevier
Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …

Toll-like receptors, transduction-effector pathways, and disease diversity: evidence of an immunobiological paradigm explaining all human illness?

TJ Atkinson - International Reviews of Immunology, 2008 - Taylor & Francis
Membrane-bound Toll-like receptors (TLRs) are frontline guardians in the mammalian
innate immune system. They primarily function to recognize pathogen-associated molecular …

'Toll'gates for future immunotherapy

KJ Ishii, S Uematsu, S Akira - Current pharmaceutical design, 2006 - ingentaconnect.com
Toll-like receptors (TLRs) are evolutionary conserved transmembrane proteins that
recognize a unique pattern of molecules derived from pathogens or damaged cells …

When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

LAJ O'Neill - Immunity, 2008 - cell.com
Toll-like receptor (TLR) signaling is subjected to crosstalk from other signals, with a resulting
positive or negative effect. There is complex crosstalk between the NLR family of immune …

Novel drugs targeting Toll-like receptors for antiviral therapy

MC Patel, KA Shirey, LM Pletneva… - Future …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that
recognize conserved'pathogen-associated molecular patterns' of invading microbes …

Prophylactic and therapeutic implications of toll‐like receptor ligands

M Hedayat, K Takeda, N Rezaei - Medicinal research reviews, 2012 - Wiley Online Library
The evolutionary conserved Toll‐like receptors (TLRs) are the first identified and best
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …

Recent progress in the development of Toll-like receptor (TLR) antagonists

MC Patra, S Choi - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
ABSTRACT Introduction: Pattern recognition receptors (PRRs) of the innate immune system
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …

Is targeting Toll‐like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine‐driven inflammation?

E Andreakos, B Foxwell, M Feldmann - Immunological reviews, 2004 - Wiley Online Library
Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …