Recent clinical trends in Toll‐like receptor targeting therapeutics
Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …
Immunobiology of Toll‐like receptors: emerging trends
S Pandey, DK Agrawal - Immunology and Cell Biology, 2006 - Wiley Online Library
Toll‐like receptors (TLR), a family of evolutionarily conserved pathogen recognition
receptors, play pivotal role as primary sensors of invading pathogens. TLR identify …
receptors, play pivotal role as primary sensors of invading pathogens. TLR identify …
Revolutionizing medicine with toll-like receptors: A path to strengthening cellular immunity
JA Malik, G Kaur, JN Agrewala - International Journal of Biological …, 2023 - Elsevier
Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …
system's defense against pathogens and maintenance of homeostasis. The interaction …
Toll-like receptors, transduction-effector pathways, and disease diversity: evidence of an immunobiological paradigm explaining all human illness?
TJ Atkinson - International Reviews of Immunology, 2008 - Taylor & Francis
Membrane-bound Toll-like receptors (TLRs) are frontline guardians in the mammalian
innate immune system. They primarily function to recognize pathogen-associated molecular …
innate immune system. They primarily function to recognize pathogen-associated molecular …
'Toll'gates for future immunotherapy
Toll-like receptors (TLRs) are evolutionary conserved transmembrane proteins that
recognize a unique pattern of molecules derived from pathogens or damaged cells …
recognize a unique pattern of molecules derived from pathogens or damaged cells …
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction
LAJ O'Neill - Immunity, 2008 - cell.com
Toll-like receptor (TLR) signaling is subjected to crosstalk from other signals, with a resulting
positive or negative effect. There is complex crosstalk between the NLR family of immune …
positive or negative effect. There is complex crosstalk between the NLR family of immune …
Novel drugs targeting Toll-like receptors for antiviral therapy
MC Patel, KA Shirey, LM Pletneva… - Future …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
Prophylactic and therapeutic implications of toll‐like receptor ligands
M Hedayat, K Takeda, N Rezaei - Medicinal research reviews, 2012 - Wiley Online Library
The evolutionary conserved Toll‐like receptors (TLRs) are the first identified and best
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
Recent progress in the development of Toll-like receptor (TLR) antagonists
ABSTRACT Introduction: Pattern recognition receptors (PRRs) of the innate immune system
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
Is targeting Toll‐like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine‐driven inflammation?
E Andreakos, B Foxwell, M Feldmann - Immunological reviews, 2004 - Wiley Online Library
Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …