The complement system is thought to be involved in the pathogenesis of numerous
neurological diseases, although its precise role remains controversial. In this study we used …

C5a receptors are found in the central nervous system (CNS), on both neurons and glia.
However, the origin of the C5a, which activates these receptors, is unclear. In the present …

In this study we explored the potential role of the complement derived anaphylatoxin C5a
and the expression of its receptor in mouse brain. Using in situ hybridization, we found that …

The complement system is a pivotal component of the innate immune system which protects
the host from infection and injury. Complement proteins can be induced in all cell types …

There is evidence that the complement system, a major component of inflammatory
responses, may play an important role in neurodegenerative conditions such as Alzheimer's …

The present studies were undertaken to determine whether neuronal subsets in normal
brains constitutively express functionally competent C5a receptors. In situ hybridization …

In our earlier results, we demonstrated that cells expressing the complement C5aR are
vulnerable since abnormal activation of C5aR caused apoptosis of these cells. In this study …

Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Possible roles of the complement (C) system in the normal and injured brain were explored
with inbred mice that carried a frameshift mutation in the C5 gene. A congenic pair was …