[HTML][HTML] Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
CM Gay, CA Stewart, EM Park, L Diao, SM Groves… - Cancer cell, 2021 - cell.com
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a
single entity with predictably poor results. Using tumor expression data and non-negative …
single entity with predictably poor results. Using tumor expression data and non-negative …
[HTML][HTML] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
Small cell lung cancer: Subtypes and therapeutic implications
WZ Wang, A Shulman, JM Amann, DP Carbone… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
Targeted therapies and biomarkers in small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid growth,
early metastasis, and acquired therapeutic resistance. A majority of patients with SCLC have …
early metastasis, and acquired therapeutic resistance. A majority of patients with SCLC have …
Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease
Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality.
Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy …
Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy …
Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions
Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade
Summary Atezolizumab (anti-PD-L1), combined with carboplatin and etoposide (CE), is now
a standard of care for extensive-stage small-cell lung cancer (ES-SCLC). A clearer …
a standard of care for extensive-stage small-cell lung cancer (ES-SCLC). A clearer …
Molecular profiles of small cell lung cancer subtypes: therapeutic implications
A Schwendenwein, Z Megyesfalvi, N Barany… - Molecular Therapy …, 2021 - cell.com
Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers)
is an exceptionally lethal malignancy characterized by rapid doubling time and high …
is an exceptionally lethal malignancy characterized by rapid doubling time and high …
Emerging biomarkers and the changing landscape of small cell lung cancer
A Keogh, S Finn, T Radonic - Cancers, 2022 - mdpi.com
Simple Summary Small cell lung cancer (SCLC) is an aggressive cancer representing 15%
of all lung cancers. Unlike other types of lung cancer, treatments for SCLC have changed …
of all lung cancers. Unlike other types of lung cancer, treatments for SCLC have changed …
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study
Z Megyesfalvi, N Barany, A Lantos… - The Journal of …, 2022 - Wiley Online Library
The tissue distribution and prognostic relevance of subtype‐specific proteins (ASCL1,
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …