The finding that cyclooxygenase-2 (COX-2) is over-expressed and plays an important role in
carcinogenesis in gastrointestinal (GI) cancers including esophagus, gastric and colorectal …

Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …

Background and aims. Discovery of an isoform of Cyclo-oxygenase (COX) 1, the inducible
COX-2, has made it possible to avoid some side effects of non-specific COX inhibitors. The …

Epidemiological evidences suggest that chronic use of aspirin and nonsteroidal anti-
inflammatory drugs (NSAIDs) might be associated with a reduced risk of gastrointestinal …

Epidemiological studies have shown that the regular use of nonsteroidal anti-inflammatory
drugs (NSAIDs) is associated with a reduction of gastrointestinal cancer risk. Since up …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

COX-2 is upregulated at an early stage in colorectal carcinogenesis and generates
prostaglandins, which promote cancer cell proliferation, impair apoptosis and enhance …

Prior to the discovery of cyclooxygenase-2 (COX-2), a beneficial association was shown
between chronic usage of non steroidal anti-inflammatory drugs (NSAIDs), that …

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for
esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of …

Multiple lines of evidence suggest that aberrant induction and upregulation of the
prostaglandin cascade play a significant role in colon and mammary carcinogenesis, and …