The prevalence of intolerance varies widely. Stopping statin therapy is associated with
worse outcomes in patients with cardiovascular disease. Despite extensive studies, the …

Background Statin intolerance is a barrier to effective lipid-lowering treatment. A significant
number of patients stop prescribed statins, or can take only a reduced dose, because of …

Background Statin intolerance is a key barrier to the effective prevention of atherosclerotic
cardiovascular disease (ASCVD). Experts do not agree on what it is and how to respond to …

Statin therapy is generally well tolerated and very effective in the prevention and treatment of
cardiovascular disease, regardless of cholesterol levels; however, it can be associated with …

Few controversies in contemporary cardiovascular medicine provoke the extreme reactions
and intense disagreement as the concept of muscle-related statin intolerance. On one side …

Statins are the first‐line pharmacotherapy for cholesterol reduction. Use of these drugs in
large randomized clinical trials has consistently shown significant reductions in major …

Background and aims There is disquiet about statin effectiveness and side effects in both the
medical and lay media. Methods We searched the literature for reports on the incidence of …

Abstract The Proceedings of a Canadian Working Group Consensus Conference, first
published in 2011, provided a summary of statin-associated adverse effects and intolerance …

Statin therapy is perhaps the most beneficial therapy in all of cardiology. In numerous large
randomized trials, lowering low density lipoprotein cholesterol (LDL-C) with statins (or other …

Despite the efficacy of statins in reducing cardiovascular events in both primary and
secondary prevention, the adherence to statin therapy is not optimal, mainly due to the …