Follicular helper T (TFH) cells are a class of helper T cells specialized in the cognate control
of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells …

T follicular helper (Tfh) cells provide help to B cells and are crucial for establishment of
germinal center (GC) reactions, including production of high-affinity antibodies and …

Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-
wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh …

Effective humoral immunity depends on the support of B cell responses by T follicular helper
(Tfh) cells. Although it has been proposed that Tfh cell differentiation requires TB …

Follicular T‐helper (TFH) cells play a crucial role in three aspects of the germinal center
(GC) response. They promote GC formation, arbitrate competition among GC B cells to …

CD4+ T cells can differentiate into numerous subsets characterized by expression of a suite
of cytokines and effector molecules that endow them with specialized functions. By …

Follicular helper T cells regulate high-affinity antibody production. Memory follicular helper T
cells can be local in draining lymphoid organs and circulate in the blood, but the underlying …

B helper follicular T (Tfh) cells are critical for long-term humoral immunity. However, it
remains unclear how these cells are recruited and contribute to secondary immune …

The generation of high-affinity antibodies (Abs) plays a critical role in the neutralization and
clearance of pathogens and subsequent host survival after natural infection with a variety of …

High affinity antibodies result from interactions between B cells and T follicular helper (Tfh)
cells in germinal centers (GCs). Recent studies have identified an effector subset of T …