Background and aim Resveratrol (RSV), is a stilbene-based compound exerting wide
biological properties. Its analogue 4, 4′-dihydroxy-trans-stilbene (DHS) has shown …

The sirtuin family Nicotinamide adenine dinucleotide-dependent deacetylases have
important roles in many biological processes (Milne and Denu, 2008). SIRT1 is a …

The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many
cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell …

Sirtuins are protein deacetylases regulating aging processes and various physiological
functions. Resveratrol, a polyphenol found in red wine, activates human Sirt1 and inhibits …

The phytoalexin resveratrol has been described to have chemopreventive and
chemotherapeutic effects in several tumor models while its effects on osteosarcoma have …

Resveratrol is a plant polyphenol capable of exerting beneficial metabolic effects which are
thought to be mediated in large by the activation of the NAD+‐dependent protein …

Resveratrol produces substantial metabolic benefits in rodent models, and there have been
positive indications in several small human trials, yet the mechanism of action for this …

Four different classes of HDACs have been identified in humans so far. Classes I, II and IV
are zinc-dependent amidohydrolases, while III is a family of phylogenetically conserved …

SIRT1, a member of the sirtuin family, catalyzes the deacetylation of proteins with the
transformation of NAD+ into nicotinamide and 2′-O-acetyl-ADP-ribose. Selective SIRT1/2 …

SIRT1 is the closest mammalian homologue of enzymes that extend life in lower organisms.
Its role in mammals is incompletely understood, but includes modulation of at least 34 …