Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens

K Keita, C Darkoh, F Okafor - SN Applied Sciences, 2022 - Springer
Antibiotic resistance is a major public health threat of the twenty-first century and represents
an important risk to the global economy. Healthcare-associated infections mainly caused by …

New natural products as new leads for antibacterial drug discovery

DG Brown, T Lister, TL May-Dracka - Bioorganic & medicinal chemistry …, 2014 - Elsevier
Natural products have been a rich source of antibacterial drugs for many decades, but
investments in this area have declined over the past two decades. The purpose of this …

Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022

S Woo, L Marquez, WJ Crandall, CJ Risener… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2018 to 2022Antimicrobial resistance (AMR) poses a significant global health
threat. There is a rising demand for innovative drug scaffolds and new targets to combat …

A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery

U Anand, N Jacobo-Herrera, A Altemimi, N Lakhssassi - Metabolites, 2019 - mdpi.com
The war on multidrug resistance (MDR) has resulted in the greatest loss to the world's
economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a …

[HTML][HTML] Developing new antimicrobial therapies: are synergistic combinations of plant extracts/compounds with conventional antibiotics the solution?

MJ Cheesman, A Ilanko, B Blonk… - Pharmacognosy reviews, 2017 - ncbi.nlm.nih.gov
The discovery of penicillin nearly 90 years ago revolutionized the treatment of bacterial
disease. Since that time, numerous other antibiotics have been discovered from bacteria …

Antimicrobial natural products: an update on future antibiotic drug candidates

M Saleem, M Nazir, MS Ali, H Hussain, YS Lee… - Natural product …, 2010 - pubs.rsc.org
Covering: 2000 to 2008 Over the last decade, it has become clear that antimicrobial drugs
are losing their effectiveness due to the evolution of pathogen resistance. There is therefore …

Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants

W Huang, Y Wang, W Tian, X Cui, P Tu, J Li, S Shi… - Antibiotics, 2022 - mdpi.com
The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …

[HTML][HTML] A systematic review of plants with antibacterial activities: A taxonomic and phylogenetic perspective

F Chassagne, T Samarakoon, G Porras… - Frontiers in …, 2021 - frontiersin.org
Background: Antimicrobial resistance represents a serious threat to human health across the
globe. The cost of bringing a new antibiotic from discovery to market is high and return on …

Opportunities for natural products in 21 st century antibiotic discovery

GD Wright - Natural product reports, 2017 - pubs.rsc.org
Natural products and their derivatives are mainstays of our antibiotic drugs, but they are
increasingly in peril. The combination of widespread multidrug resistance in once …