Synthesis, biological and computational evaluation of benzoxazole hybrid analogs as potential anti-Alzheimer's agents
Aim: Current study aims exploration of bis-benzoxazole bearing bis-Schiff base scaffolds (1–
16) as anti-Alzheimer's agents. Materials & methods: 2-aminophenol is used as starting …
16) as anti-Alzheimer's agents. Materials & methods: 2-aminophenol is used as starting …
Design, Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Study of Benzimidazole-Based Oxazole Analogues: A Promising …
Alzheimer's disease (AD) is a degenerative neurological condition that severely affects the
elderly and is clinically recognised by a decrease in cognition and memory. The treatment of …
elderly and is clinically recognised by a decrease in cognition and memory. The treatment of …
[HTML][HTML] Design, Synthesis, in vitro biological evaluation and in silico molecular docking study of chloro substituted Benzimidazole-Thiazole hybrid derivatives as …
In order to explore new acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)
inhibitors, a series of benzimidazole-fused-thiazole bearing Schiff base derivatives (1–16) …
inhibitors, a series of benzimidazole-fused-thiazole bearing Schiff base derivatives (1–16) …
Recent development and strategies towards target interactions: Synthesis, characterization and in silico analysis of benzimidazole based thiadiazole as potential anti …
In the current research study, we aim to design and synthesize highly potent hybrid analogs
of benzimidazole derived thiadiazole based Schiff base derivatives which can combat the …
of benzimidazole derived thiadiazole based Schiff base derivatives which can combat the …
[HTML][HTML] Synthesis, in vitro analysis and molecular docking study of novel benzoxazole-based oxazole derivatives for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is treated by targeting cholinesterase enzymes like
acetylcholinesterase and butyrylcholinesterase, and these enzymes' inhibitors serve as …
acetylcholinesterase and butyrylcholinesterase, and these enzymes' inhibitors serve as …
[HTML][HTML] A promising acetylcholinesterase and butyrylcholinesterase inhibitors: In vitro enzymatic and in silico molecular docking studies of benzothiazole-based …
Abstract Alzheimer's dementia (AD), the most prevalent neurodegenerative disorder
adversely affecting elderly citizens worldwide, is an incurable disorder with no effective …
adversely affecting elderly citizens worldwide, is an incurable disorder with no effective …
Investigation of novel benzoxazole-oxadiazole derivatives as effective anti-Alzheimer's agents: in vitro and in silico approaches
Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …
by cognitive and memory decline and adversely affects the people of old age. The …
Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-Alzheimer potential with molecular mechanism of protein ligand profile
As a springboard to explore novel potent inhibitors of cholinesterase enzymes (AChE and
BChE) responsible for causing Alzheimer disorder, the current study was conducted to …
BChE) responsible for causing Alzheimer disorder, the current study was conducted to …
Structure-based inhibition of acetylcholinesterase and butyrylcholinesterase with 2-Aryl-6-carboxamide benzoxazole derivatives: synthesis, enzymatic assay, and in …
An important research topic is the discovery of multifunctional compounds targeting different
disease-causing components. This research aimed to design and synthesize a series of 2 …
disease-causing components. This research aimed to design and synthesize a series of 2 …
Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies
Acetylcholinesterase and butyrylcholinesterase enzymes are therapeutic target for
Alzheimer disease and their inhibitors play a vital role for the treatment of this disease. A …
Alzheimer disease and their inhibitors play a vital role for the treatment of this disease. A …