Characterizing and modeling bone formation during mouse calvarial development

A Marghoub, J Libby, C Babbs, Y Ventikos, MJ Fagan… - Physical review …, 2019 - APS
The newborn mammalian cranial vault consists of five flat bones that are joined together
along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to …

Craniosynostosis and resynostosis: models, imaging, and dental implications

CD Hermann, SL Hyzy… - Journal of dental …, 2016 - journals.sagepub.com
Craniosynostosis occurs in approximately 1 in 2,000 children and results from the premature
fusion of≥ 1 cranial sutures. If left untreated, craniosynostosis can cause numerous …

Hybrid simulation of brain–skull growth

J Jin, S Shahbazi, J Lloyd, S Fels… - …, 2014 - journals.sagepub.com
This paper describes a hybrid model that includes both a standard finite element model and
also volume-preserving structural modeling for a clinical application involving skull …

[HTML][HTML] Personalized bone reconstruction and regeneration in the treatment of craniosynostosis

F Tiberio, I Cacciotti, P Frassanito, G Nocca… - Applied Sciences, 2021 - mdpi.com
Featured Application This review outlines the extant techniques and innovative
biotechnologies to implement the surgical treatment of craniosynostosis and related …

[HTML][HTML] Multiscale mechanical characterisation of the craniofacial system under external forces

M Didziokas, D Jones, A Alazmani, M Steacy… - … and Modeling in …, 2024 - Springer
Premature fusion of craniofacial joints, ie sutures, is a major clinical condition. This condition
affects children and often requires numerous invasive surgeries to correct. Minimally …

Spring assisted cranioplasty: a patient specific computational model

A Borghi, N Rodriguez-Florez, W Rodgers… - Medical Engineering & …, 2018 - Elsevier
Implantation of spring-like distractors in the treatment of sagittal craniosynostosis is a novel
technique that has proven functionally and aesthetically effective in correcting skull …

Virtual modeling, stereolithography, and intraoperative CT guidance for the optimization of sagittal synostosis reconstruction: a technical note

AJ Kobets, A Ammar, J Nakhla, A Scoco, R Nasser… - Child's Nervous …, 2018 - Springer
Introduction Sagittal synostosis affects 1 in 1000 live births and may result in increased
intracranial pressure, hindrance of normal neural development, and cosmetic deformity due …

Predicting calvarial growth in normal and craniosynostotic mice using a computational approach

A Marghoub, J Libby, C Babbs, E Pauws… - Journal of …, 2018 - Wiley Online Library
During postnatal calvarial growth the brain grows gradually and the overlying bones and
sutures accommodate that growth until the later juvenile stages. The whole process is …

Cranial growth in isolated sagittal craniosynostosis compared with normal growth in the first 6 months of age

E Mercan, RA Hopper, AM Maga - Journal of anatomy, 2020 - Wiley Online Library
Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture
fusion, results in abnormal head shape that requires extensive surgery to correct. It is …

[HTML][HTML] The biomechanics of chewing and suckling in the infant: A potential mechanism for physiologic metopic suture closure

PN Haravu, M Gonzalez, SL Nathan… - PLOS Computational …, 2023 - journals.plos.org
Craniosynostosis is a condition with neurologic and aesthetic sequelae requiring invasive
surgery. Understanding its pathobiology requires familiarity with the processes underlying …