Epigenetic modifications of histones regulate gene expression and chromatin structure,.
Here we show that Meisetz (meiosis-induced factor containing a PR/SET domain and zinc …

A unique feature of the germ cell lineage is the generation of totipotency. A critical event in
this context is DNA demethylation and the erasure of parental imprints in mouse primordial …

In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …

Because nucleosomes are widely replaced by protamine in mature human sperm, the
epigenetic contributions of sperm chromatin to embryo development have been considered …

Meiosis is a germ-cell-specific cell division process through which haploid gametes are
produced for sexual reproduction. Before the initiation of meiosis, mouse primordial germ …

DNA methylation inhibits gene expression in animal cells, probably by affecting chromatin
structure. Biochemical studies suggest that this process may be mediated by methyl-specific …

Lysine methylation of histones in vivo occurs in three states: mono-, di-and tri-methyl.
Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic …

Stability of the epigenetic landscape underpins maintenance of the cell-type-specific
transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation …

Variation in patterns of methylations of histone tails reflects and modulates chromatin
structure and function. To provide a framework for the analysis of chromatin function in …

Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event
that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby …