Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic
reticulum (ER)–mitochondrion signaling affects intramitochondrial calcium (Ca 2+) …

Abstract The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the
mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and …

Communication between the endoplasmic reticulum (ER) and mitochondrion is important for
bioenergetics and cellular survival. The ER supplies Ca 2+ directly to mitochondria via …

Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …

After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions
are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein …

Cell excitability is tightly regulated by the activity of ion channels that allow for the passage
of ions across cell membranes. Ion channel activity is controlled by different mechanisms …

Abstract The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …

The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein. It is
a non-ATP-binding nonglycosylated ligand-regulated molecular chaperone of unknown …

The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with
mitochondria whereby the contact is referred to as the m itochondrion-a ssociated ER m …

The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …