The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer
HY Yong, MS Koh, A Moon - Expert opinion on investigational …, 2009 - Taylor & Francis
Background: The p38 mitogen-activated protein kinase (MAPK) is activated by various pro-
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
B Kaminska - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2005 - Elsevier
Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
p38 MAP kinase inhibitors: many are made, but few are chosen.
C Dominguez, DA Powers, N Tamayo - Current opinion in drug …, 2005 - europepmc.org
The mitogen-activated protein kinase (MAPK) p38 is a Ser/Thr kinase, originally isolated
from lipopolysaccharide-stimulated monocytes. There are four isoforms of the enzyme …
from lipopolysaccharide-stimulated monocytes. There are four isoforms of the enzyme …
p38MAPK: stress responses from molecular mechanisms to therapeutics
LR Coulthard, DE White, DL Jones… - Trends in molecular …, 2009 - cell.com
The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …
recognized roles in inflammation, cell-cycle regulation, cell death, development …
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
S Kumar, J Boehm, JC Lee - Nature reviews Drug discovery, 2003 - nature.com
The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …
roles in cellular responses to external stress signals. Since their identification about 10 years …
Novel strategies for inhibition of the p38 MAPK pathway
J Zhang, B Shen, A Lin - Trends in pharmacological sciences, 2007 - cell.com
The p38 subgroup of the mitogen-activated protein kinase superfamily has four isoforms:
p38α, p38β, p38δ and p38γ. Whereas p38α is involved in inflammation, proliferation …
p38α, p38β, p38δ and p38γ. Whereas p38α is involved in inflammation, proliferation …
Map kinase p38inhibitors: Clinical results and an intimate look at their interactions with p38α protein
MR Lee, C Dominguez - Current medicinal chemistry, 2005 - ingentaconnect.com
Mitogen-activated protein kinase p38 is a serine/threonine kinase originally isolated from
lipopolysaccharide (LPS) stimulated monocytes. There are four isoforms p38α, p38β, p38γ …
lipopolysaccharide (LPS) stimulated monocytes. There are four isoforms p38α, p38β, p38γ …
Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease
M Fisk, PR Gajendragadkar, KM Mäki-Petäjä… - American Journal of …, 2014 - Springer
Abstract p38 mitogen-activated protein kinases (p38 MAPKs) are key signalling molecules
that regulate cellular behavior in response to environmental stresses. They regulate pro …
that regulate cellular behavior in response to environmental stresses. They regulate pro …
The p38 MAPK components and modulators as biomarkers and molecular targets in cancer
L García-Hernández, MB García-Ortega… - International journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) family is an important bridge in the
transduction of extracellular and intracellular signals in different responses at the cellular …
transduction of extracellular and intracellular signals in different responses at the cellular …
Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity
RM Campbell, BD Anderson, NA Brooks… - Molecular cancer …, 2014 - AACR
Abstract p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in
response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α …
response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α …