Urine metabolomics has recently emerged as a prominent field for the discovery of non‐
invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific …

Metabolomics is a powerful technique for the discovery of novel biomarkers and elucidation
of biochemical pathways to improve diagnosis, prognosis and therapy. An advantage of this …

Among all the human biological fluids used for disease biomarker discovery or clinical
chemistry, urine stands out. It can be collected easily and noninvasively, it is readily …

Background Human urine gives evidence of the metabolism in the body and contains
different metabolites at various concentrations. A number of analytical techniques including …

Analysis of urine is a widely used diagnostic tool that traditionally measured one or, at most,
a few metabolites. However, the recognition of the need for a holistic approach to …

Steps preceding introduction of the analytical sample into individual separation equipment
and/or mass-spectrometry (MS) detectors for targeted or untargeted metabolomics studies …

Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-
to-obtain in large volumes, largely free from interfering proteins or lipids and chemically …

Urine is a popular biofluid for metabolomics studies due to its simple, non-invasive collection
and its availability in large quantities, permitting frequent sampling, replicate analyses, and …

NMR-based metabolomics has shown considerable promise in disease diagnosis and
biomarker discovery because it allows one to nondestructively identify and quantify large …

Currently, most clinical studies in metabolomics only consider a single type of sample such
as urine, plasma, or feces and use a single analytical platform, either NMR or MS. Although …