Cryptococcus neoformans Gene Expression during Murine Macrophage Infection

W Fan, PR Kraus, MJ Boily, J Heitman - Eukaryotic cell, 2005 - Am Soc Microbiol
The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and
proliferates within, ultimately establishing latent infection as a facultative intracellular …

[HTML][HTML] The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during Infection

GJC Freitas, L Gouveia-Eufrasio, ECP Emidio… - Cells, 2022 - mdpi.com
The phenotypic plasticity of Cryptococcus neoformans is widely studied and demonstrated in
vitro, but its influence on pathogenicity remains unclear. In this study, we investigated the …

Morphology and its underlying genetic regulation impact the interaction between Cryptococcus neoformans and its hosts

J Lin, A Idnurm, X Lin - Medical mycology, 2015 - academic.oup.com
Cryptococcus neoformans is a fungus that causes the majority of fatal cryptococcal
meningitis cases worldwide. This pathogen is capable of assuming different morphotypes …

[HTML][HTML] PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex

C Fu, J Heitman - PLoS Genetics, 2017 - journals.plos.org
Sexual reproduction is critical for successful evolution of eukaryotic organisms in adaptation
to changing environments. In the opportunistic human fungal pathogens, the Cryptococcus …

[HTML][HTML] Cryptococcus neoformans Mediator Protein Ssn8 Negatively Regulates Diverse Physiological Processes and Is Required for Virulence

LI Wang, YS Lin, KH Liu, AY Jong, WC Shen - PLoS One, 2011 - journals.plos.org
Cryptococcus neoformans is a ubiquitously distributed human pathogen. It is also a model
system for studying fungal virulence, physiology and differentiation. Light is known to inhibit …

A MAP kinase cascade composed of cell type specific and non‐specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans

RC Davidson, CB Nichols, GM Cox… - Molecular …, 2003 - Wiley Online Library
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle in
which the α allele of the mating type locus is linked to virulence and haploid differentiation …

[HTML][HTML] Phenotypic characterization of HAM1, a novel mating regulator of the fungal pathogen Cryptococcus neoformans

EA Yee, RL Ross, FH Santiago-Tirado - bioRxiv, 2024 - ncbi.nlm.nih.gov
Cryptococcus neoformans is a fungal pathogen responsible for> 200,000 yearly cases with
a mortality as high as 81%. This burden results, in part, from an incomplete understanding of …

Intersection of fungal fitness and virulence in Cryptococcus neoformans

JC Panepinto, PR Williamson - FEMS yeast research, 2006 - academic.oup.com
The use of insertional mutagenesis to discover genes that impact laccase activity has
resulted in the identification of multiple cellular processes that affect the fitness of …

The Ess1 prolyl isomerase is dispensable for growth but required for virulence in Cryptococcus neoformans

P Ren, A Rossettini, V Chaturvedi… - Microbiology, 2005 - microbiologyresearch.org
Cryptococcus neoformans is an important human fungal pathogen that also serves as a
model for studies of fungal pathogenesis. C. neoformans contains several genes encoding …

The interplay of phenotype and genotype in Cryptococcus neoformans disease

S Altamirano, KM Jackson, K Nielsen - Bioscience Reports, 2020 - portlandpress.com
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …