Biocatalysis is an effective tool to access chiral molecules that are otherwise hard to
synthesize or purify. Time-efficient processes are needed to develop enzymes that …

Finding faster and simpler ways to screen protein sequence space to enable the
identification of new biocatalysts for asymmetric synthesis remains both a challenge and a …

Imine reductases catalyse the reductive amination of aldehydes or ketones with amines to
produce chiral amines—a key transformation in the preparation of fine chemicals and active …

Reducing reactions are among the most useful transformations for the generation of chiral
compounds in the fine‐chemical industry. Because of their exquisite selectivities, enzymatic …

Imine reductases (IREDs) have shown great potential as catalysts for the asymmetric
synthesis of industrially relevant chiral amines, but a limited understanding of sequence …

Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …

Chiral secondary and tertiary amines are ubiquitous in pharmaceutical, fine, and specialty
chemicals, but their synthesis typically suffers from significant sustainability and selectivity …

Biocatalysis has emerged as a powerful alternative to traditional chemistry, especially for
asymmetric synthesis. One key requirement during process development is the discovery of …

The combination of computational design and laboratory evolution is a powerful and
potentially versatile strategy for the development of enzymes with new functions …

Imine reductases (IREDs) have recently become a primary focus of research in biocatalysis,
complementing other classes of amine‐forming enzymes such as transaminases and amine …