Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study

JR Boike, R Kao, D Meyer, B Markle… - Alimentary …, 2012 - Wiley Online Library
Background Paracetamol is commonly prescribed for first‐line symptomatic treatment in
patients with osteoarthritis and aspirin is often co‐administered for cardiovascular …

Investigation of gastroduodenal mucosal injuries caused by low‐dose aspirin therapy in patients with cerebral infarction

H Nema, M Kato - Journal of gastroenterology and hepatology, 2010 - Wiley Online Library
Abstract Background and Aims: Low‐dose aspirin is used as a preventive treatment for
ischemic heart disease and ischemic cerebrovascular disease, on the other hand …

Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype

T Uotani, M Sugimoto, M Nishino, C Kodaira… - Clinical …, 2012 - Elsevier
BACKGROUND & AIMS: Low doses of aspirin can injure the gastric mucosa. It is not clear
whether other drugs such as the antiplatelet agent clopidogrel also cause gastric mucosal …

Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment

A Lanas, J Scheiman - Current medical research and opinion, 2007 - Taylor & Francis
ABSTRACT Background: Low-dose aspirin (75–325 mg/day) is widely used for the
prevention of cardiovascular disease. However, due to its action on cyclo-oxygenase (COX) …

Low-dose aspirin-induced gastrointestinal diseases: past, present, and future

A Shiotani, T Kamada, K Haruma - Journal of Gastroenterology, 2008 - Springer
Meta-analyses of randomized, placebo-controlled trials of low-dose aspirin indicate that
aspirin approximately doubles the risk of major GI bleeding compared with placebo. The risk …

[PDF][PDF] Correlation between serum triglycerides and gastro-duodenal ulcer associated with low-dose aspirin

T Fujii, T Nakabayashi, S Hashimoto… - Hepato …, 2009 - researchgate.net
Background/Aims: Aspirin significantly increases the risk of peptic ulcer. Since it remains to
be determined whether gastroprotective agents should be used routinely in patients without …

Rabeprazole reduces the recurrence risk of peptic ulcers associated with low-dose aspirin in patients with cardiovascular or cerebrovascular disease: a prospective …

T Sanuki, T Fujita, H Kutsumi, T Hayakumo… - Journal of …, 2012 - Springer
Background Patients using low-dose aspirin (LDA) have an increased risk of
gastroduodenal mucosal lesions and upper gastrointestinal symptoms. We aimed to clarify …

Prevention of gastric mucosal injury induced by anti‐platelet drugs by famotidine

T Uotani, M Sugimoto, M Nishino… - The Journal of …, 2014 - Wiley Online Library
Anti‐platelet drug‐induced gastric mucosal injury correlates with intragastric pH. Our aim
was to investigate prophylaxis effects of famotidine, one of the representative histamine‐2 …

Epidemiology of low dose aspirin damage in the lower gastrointestinal tract

C Sostres, A Lanas - Current pharmaceutical design, 2015 - ingentaconnect.com
Low dose aspirin (ASA), commonly defined as the cardiovascular (CV) dose of 75 to 325 mg
daily, is one of the most widely prescribed drugs in the world and the cornerstone of therapy …

Gastrointestinal effects of aspirin

C Sostres, A Lanas - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Aspirin is being used as an effective analgesic and anti-inflammatory agent at doses> 325
mg daily. At low doses (75–325 mg daily), aspirin is the key antiplatelet drug in the …