Aberrant WNT signaling underlies cancerous transformation and growth in many tissues,
such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired …

Aberrant activation of the Wnt pathway is implicated in driving the formation of various
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …

Wnt signaling is an evolutionarily conserved pathway that controls cell-to-cell interactions
during embryogenesis. In adults, Wnt signaling plays a role in tissue homeostasis in almost …

The Wnt signaling pathway is intricately involved in many aspects of development and is the
root cause of an increasing number of diseases. For example, colorectal cancer is the …

Wnts are secreted proteins that bind to cell surface receptors to activate downstream
signaling cascades. Normal Wnt signaling plays key roles in embryonic development and …

Aberrant Wnt signaling activation is frequently observed in many cancers. The mutation
acquisition of Wnt signaling leads to tumorigenesis, whereas the inhibition of Wnt signaling …

The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …

Wnt signaling plays an essential role in the initiation and progression of various types of
cancer. Besides, the Wnt pathway components have been established as reliable …

The Wnt/β-catenin signaling pathway, including canonical or noncanonical pathway, is a
highly conserved pathway which can regulate cell proliferation, migration, differentiation …

Abstract Purpose of Review Review current understanding of both canonical and non-
canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of …