Selective COX-2 inhibitors have been shown to produce fewer gastrointestinal adverse
reactionsthan classical NSAIDs. Nevertheless, these new agents may worsen and delay the …

Selective COX-2 inhibitor, celecoxib, delays the healing of gastric ulcers by inhibiting
prostaglandins synthesis. Therefore, the effect of celecoxib on normal and acid-challenged …

Five experimental models were developed in different groups of Wistar rats (N= 15) to study
selective COX-2-inhibitor NSAIDs such as celecoxib and rofecoxib, as follows:(1) dose …

Nonsteroidal anti-inflammatory drugs (NSAID) are well known to induce gastric mucosal
damage including bleeding, ulceration and perforation in humans and animals too. These …

In 5 random groups of Wistar rats (n= 15 for each group), ulcerogenic doses of NSAIDs COX-
1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); …

The influence of different nonsteroidal anti-inflammatory drugs (NSAIDs) and of a proton
pump inhibitor on the healing parameters of a chronic gastric ulcer was evaluated. Wistar …

Conclusion Dose-dependent administration of celecoxib and rofecoxib as COX-2 inhibitors
and non-COX-1 inhibitors, respectively, did not produce toxic injuries on healthy …

Celecoxib is a frequently used nonsteroidal anti-inflammatory drug (NSAID) in the treatment
of rheumatoid arthritis and osteoarthritis. It selectively inhibits cyclooxygenase II (COX-2) …

Background & Aims: Selective cyclooxygenase (COX)-2 inhibitors produce less gastric
damage than conventional nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting that …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known to induce gastrointestinal
damage including bleeding, ulceration and perforation in humans and animals. The aim of …