Patient-derived cancer organoids (PDCOs) are organotypic 3D cultures grown from patient
tumor samples. PDCOs provide an exciting opportunity to study drug response and …

Organoids are self-organizing, expanding 3D cultures derived from stem cells. Using tissue
derived from patients, these miniaturized models recapitulate various aspects of patient …

Background Patient-derived organoids are invaluable for fundamental and translational
cancer research and holds great promise for personalized medicine. However, the shortage …

Cancer harbors variable heterogeneity and plasticity. Thus far, our comprehension is greatly
based on cell lines, organoids, and patient-derived tumor xenografts (PDTXs). Organoids …

Tumor organoids are 3D cultures of cancer cells that can be derived on an individual patient
basis with a high success rate. This creates opportunities to build large biobanks with …

Background Despite recent advances in research, there are still critical lacunae in our basic
understanding of the cause, pathogenesis, and natural history of many cancers, especially …

Patient derived organoids closely resemble the biology of tissues and tumors. They are
enabling ex vivo modeling of human diseases and dissecting key features of tumor biology …

Patient‐derived organoids (PDOs) represent promising preclinical models in various tumor
types. In the context of prostate cancer (PCa), however, their establishment has been …

Cancer immunotherapy has revolutionized the field of cancer treatment in recent years.
However, not all patients receiving cancer immunotherapy exhibit durable responses, and …

Background The prognosis of patients with different gastrointestinal cancers varies widely.
Despite advances in treatment strategies, such as extensive resections and the addition of …