Purpose: West syndrome (WS) is considered an age‐dependent epileptic encephalopathy
and also a particular type of electrical epileptic status. Short‐term hormonal or steroid …

We administered zonisamide (ZNS) to patients with West syndrome in different titration
protocols and compared their short-term therapeutic effects. We designed three protocols to …

Corticotrophin (adrenocorticotropic hormone, ACTH) and β-endorphin levels of the
cerebrospinal fluid (CSF) were determined in 16 infants with the West syndrome during …

West's syndrome (WS) is an age-related epilepsy syndrome that is considered one of the
most refractory epilepsies of childhood. Although up to 25% of the cases may exhibit …

Objective To compare intravenous methylprednisolone (IVMP) with oral prednisolone (OP)
for the treatment of West syndrome. Methods In this randomized, open-label trial, children …

The long-term effectiveness of zonisamide (ZNS) was evaluated in 11 patients with West
syndrome (7 symptomatic) who had cessation of spasms with ZNS monotherapy. During the …

Results 1. WS and DS: IS had onset at a mean age of 6.5 months. No other type of seizures
was registered. EEG showed typical hypsarrhythmia in 12 cases and asymmetric …

Objective Hormonal therapy and vigabatrin are now accepted as the first-line or standard
therapies for West syndrome (WS). However, the superiority of these drugs in terms of …

We sent questionnaires about current therapy for West syndrome (WS) to 208 institutions at
which the pediatric members of the Japan Epilepsy Society were in residence. One hundred …

West syndrome (WS) is commonly associated with a poor long-term outcome including a
small but significant mortality, infantile spasms that are resistant to treatment, the …