Iron is vital for all living organisms but excess iron can be lethal because it facilitates free
radical formation. Thus iron absorption is carefully regulated to maintain an equilibrium …

Obesity is often associated with disorders of iron homeostasis; however, the underlying
mechanisms are not fully understood. Hepcidin is a key regulator of iron metabolism and …

abstract Iron deficiency anemia is the most common nutritional deficiency in humans. Not all
dietary ingested iron, heme or nonheme, will be available to absorption and negative …

The liver plays a major role in iron homeostasis; thus, in patients with chronic liver disease,
iron regulation may be disturbed. Higher iron levels are present not only in patients with …

Dietary iron is present in food both in inorganic forms as ferrous and ferric compounds, and
in organic forms, the most important of these being heme iron. The purpose of this review is …

Hereditary hemochromatosis (HH) is an autosomal recessive disorder characterized by
enhanced intestinal absorption of dietary iron. Without therapeutic intervention, iron …

Background. Iron is one of the nutrients that require special consideration in a plant-based
diet. The widespread belief is that meat is the best source of iron and a vegetarian diet …

Background: Hepcidin is a key regulator of iron homeostasis, but to date no studies have
examined the effect of hepcidin on iron absorption in humans. Objective: Our objective was …

Iron is essential for oxygen transport, oxidative metabolism, and cellular growth. Interactions
between iron and other dietary factors play a significant role in determining the adequacy of …

Heme-Fe is an important source of dietary iron in humans; however, the mechanism for
heme-Fe uptake by enterocytes is poorly understood. Heme carrier protein 1 (HCP1) was …