Deleterious versus protective autoimmunity in multiple sclerosis

M Kostic, I Stojanovic, G Marjanovic, N Zivkovic… - Cellular …, 2015 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of central
nervous system, in which myelin specific CD4+ T cells have a central role in orchestrating …

Pathophysiology of multiple sclerosis

T Korn - Journal of neurology, 2008 - Springer
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). Both genetic and environmental causes for MS have been …

Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis

M El-behi, A Rostami, B Ciric - Journal of Neuroimmune Pharmacology, 2010 - Springer
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …

Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination

A Rostami, B Ciric - Journal of the neurological sciences, 2013 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The
etiology of MS is not well understood, but it is believed that myelin-specific CD4+ T cells play …

Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target

R Liu, S Du, L Zhao, S Jain, K Sahay… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by destruction of the myelin sheath structure. The loss of myelin leads …

Role of CD4+ T cells in the pathophysiology of multiple sclerosis

F Sato, S Omura, SL Jaffe, I Tsunoda - Multiple Sclerosis, 2016 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Although the precise etiology of MS remains unclear, CD4+ T cells have been …

The plasticity of immune cell response complicates dissecting the underlying pathology of multiple sclerosis

SK Sarkar, AML Willson… - Journal of Immunology …, 2024 - Wiley Online Library
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease characterized by the
destruction of the myelin sheath of the neuronal axon in the central nervous system. Many …

Th17 cell, the new player of neuroinflammatory process in multiple sclerosis

F Jadidi‐Niaragh, A Mirshafiey - Scandinavian journal of …, 2011 - Wiley Online Library
Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of
demyelination and axonal lesion mediated by CD4+ T cells with a proinflammatory Th1 and …

Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: therapeutic implications

JL Bennett, O Stüve - Clinical neuropharmacology, 2009 - journals.lww.com
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system of uncertain etiology. There is consensus that a dysregulated …

Cell-based modulation of autoimmune responses in multiple sclerosis and experimental autoimmmune encephalomyelitis: therapeutic implications

V Mastorodemos, M Ioannou, P Verginis - Neuroimmunomodulation, 2015 - karger.com
Multiple sclerosis (MS) is a prototypic autoimmune inflammatory disorder of the central
nervous system (CNS). MS pathogenesis is a complex phenomenon that is influenced by …