The apelin receptor was initially classed as an orphan G-protein-coupled receptor, and little
was known about its physiological functions until apelin, the endogenous ligand, was …

The apelin/apelin receptor system is widely distributed and has a dominant role in
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …

Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its
receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has …

Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key
hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with …

Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the
angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …

A gene encoding a novel class a G-protein-coupled receptor was discovered in 1993 by
homology cloning and was called APJ. It was designated an “orphan” receptor until 1998 …

This article focuses on a newly discovered bioactive peptide, termed apelin, as it relates to
the cardiovascular system. Apelin, through its G-protein coupled receptor, seems to primarily …

Apelin is an adipokine that has been identified as an endogenous ligand for the orphan
receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular …

Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

Importance of the field: Apelin is a bioactive peptide known as the ligand of the G-protein-
coupled receptor APJ. In recent years, there has been a growing body of evidence regarding …