Background Cyclin E is a protein that plays a key role in the G1→ S transition of the normal
cell cycle. The product of retinoblastoma gene (pRb) is the master regulator of entry into the …

Background: There is a lack of consistency regarding the prognostic value of cyclin E
overexpression in gastric cancer (gastric cancer). Our aim was to report on this …

BACKGROUND Cyclins and wild‐type p53 are prime cell cycle regulators and may be
involved in tumorigenesis. Cyclin E is a late G1 cyclin and its abnormalities have been …

Background. To elucidate the role that cyclin E overexpression plays in the progression of
early gastric cancer, we examined the expression of cyclin E and p53, as abnormal p53 …

The cell cycle progression is regulated by interactions of specific cyclin-dependent kinases
at the G1-S and G2-M checkpoints. In addition, the cell cycle dysregulation plays a major …

Background/Aim: Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes
chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated …

Cyclin D1 and E have been found to be deregulated and overexpressed in various types of
cancers. In order to study the cell cycle regulatory mechanisms in gastric cancer, we have …

Objective: We aimed to investigate the biological significance of cell cycle regulators in
gastric carcinoma. Methods: Immunohistochemistry and TUNEL staining were performed on …

PURPOSE: Cyclin G2 and cyclin E are important cell-cycle regulators in various cancer
tissues. However, little is known about cyclin G2 expression in human gastric cancer tissues …

Cell cycle regulators cyclin D1 and cyclin E2 function in G1/S transition by activating
downstream cyclin-dependent kinases. Deregulated expression of these cyclins has been …