The poor prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is partially
attributed to the invasive and metastatic behavior of this disease. Laminin subunit beta-3 …

The poor prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is primarily
due to the invasive and metastatic behaviors of this disease. Laminin‑332 (LM‑332) is a key …

Gastric cancer is the fifth most common cancer worldwide with a poor survival rate.
Therefore, it is important to identify predictive and prognostic biomarkers of gastric cancer …

Aberrant expression of laminin-332 promotes tumour growth and metastasis in multiple
cancers. However, the dysregulated expression and mechanism of action of LAMB3, which …

Hepatocellular carcinoma (HCC), the most common aggressive malignancy of liver, is the
third leading cause of cancer death across the world. Laminin gamma 1 (Lamc1), encodes …

Pancreatic ductal adenocarcinoma (PDAC) is correlated with poor outcomes because of
limited therapeutic options. Laminin-5 gamma-2 (LAMC2) plays a critical role in key …

LAMC2, as a unique chain in the Laminin 5 molecule, has been found to be associated with
malignant metastases in some cancers. However, the roles and mechanisms by which …

The LAMB3 and LAMC2 genes encode the laminin-5 β3 and γ2 chains, respectively, which
are parts of laminin-5, one of the major components of the basement membrane zone. Here …

Pancreatic cancer has a poor prognosis. It is reported that the PI3K/Akt pathway is activated
in many cancers, and inhibition of the PI3K/Akt pathway can induce cell apoptosis in most …

Hepatic metastatic growth is dependent upon stromal factors including the matrisomal
proteins that make up the extracellular matrix (ECM). Laminins are ECM glycoproteins with …