Neuronal Cross-talk within the Trigeminal Ganglia Contributes to Inflammatory Mechanical Allodynia

M Takeda, S Matsumoto - Journal of Oral Biosciences, 2008 - Elsevier
Mechanical allodynia is defined as pain caused by stimuli that do not normally evoke pain
and that are mediated by the activation of low-threshold mechanoreceptive Aβ-fibers …

Activation of NK1 receptor of trigeminal root ganglion via substance P paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint …

M Takeda, T Tanimoto, M Nasu, M Ikeda, J Kadoi… - Pain, 2005 - journals.lww.com
The aim of this study was to investigate whether under in vivo conditions,
temporomandibular joint (TMJ) inflammation alters the excitability of Aβ-trigeminal root …

Temporomandibular joint inflammation potentiates the excitability of trigeminal root ganglion neurons innervating the facial skin in rats

M Takeda, T Tanimoto, M Ikeda… - Journal of …, 2005 - journals.physiology.org
The aim of this study was to test the hypothesis that temporomandibular joint (TMJ)
inflammation alters the excitability of trigeminal root ganglion (TRG) neurons innervating the …

[HTML][HTML] P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats

M Koizumi, S Asano, A Furukawa, Y Hayashi… - The Journal of …, 2021 - Springer
Background Trigeminal neuralgia is a characteristic disease that manifests as orofacial
phasic or continuous severe pain triggered by innocuous orofacial stimulation; its …

[HTML][HTML] Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain

Y Zhang, N Song, F Liu, J Lin, M Liu, C Huang… - International journal of …, 2019 - nature.com
Inflammatory orofacial pain, in which substance P (SP) plays an important role, is closely
related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells …

Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats

M Takeda, T Tanimoto, M Nasu, S Matsumoto - European journal of pain, 2008 - Elsevier
Voltage-gated K+ (Kv) channels are one of the important physiological regulators of the
membrane potentials in excitable cells, including sensory ganglion neurons. The aim of the …

Activation of the RAS/B‐RAF‐MEK‐ERK pathway in satellite glial cells contributes to substance p‐mediated orofacial pain

Y Zhang, N Song, F Liu, J Lin, M Liu… - European Journal of …, 2020 - Wiley Online Library
The cross talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs) is
crucial for the regulation of inflammatory orofacial pain. Substance P (SP) plays an important …

Functional involvement of nucleus tractus solitarii neurons projecting to the parabrachial nucleus in trigeminal neuropathic pain

S Okada, A Katagiri, H Saito, J Lee, K Ohara… - Journal of Oral …, 2019 - jstage.jst.go.jp
Peripheral nerve injury can induce neuroplastic changes in the central nervous system and
result in neuropathic pain. This study investigated functional involvement in dorsal …

Peripheral and central mechanisms of trigeminal neuropathic and inflammatory pain

M Takeda, S Matsumoto, BJ Sessle, M Shinoda… - Journal of oral …, 2011 - Elsevier
While physiological pain (nociceptive pain) has a protective role in warning of potential
tissue damage in response to a variety of noxious stimuli, pathological pain (neuropathic …

Trigeminal somatosensation in the temporomandibular joint and associated disorders

SK Perry, JJ Emrick - Frontiers in Pain Research, 2024 - frontiersin.org
The temporomandibular joint (TMJ) consists of bone, cartilage, ligaments, and associated
masticatory muscles and tendons that coordinate to enable mastication in mammals. The …