Dipeptidyl peptidase 4 (DPP4) as A novel adipokine: role in metabolism and fat homeostasis

I Barchetta, FA Cimini, S Dule, MG Cavallo - Biomedicines, 2022 - mdpi.com
Dipeptidyl peptidase 4 (DPP4) is a molecule implicated in the regulation of metabolic
homeostasis and inflammatory processes, and it exerts its main action through its enzymatic …

Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome

D Lamers, S Famulla, N Wronkowitz, S Hartwig… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Comprehensive proteomic profiling of the human adipocyte secretome
identified dipeptidyl peptidase 4 (DPP4) as a novel adipokine. This study assessed the …

Metabolic role of dipeptidyl peptidase 4 (DPP4) in primary human (pre) adipocytes

P Zilleßen, J Celner, A Kretschmann, A Pfeifer… - Scientific reports, 2016 - nature.com
Abstract Dipeptidyl peptidase 4 (DPP4) is the target of the gliptins, a recent class of oral
antidiabetics. DPP4 (also called CD26) was previously characterized in immune cells but …

Adipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro

H Sell, M Blüher, N Klöting, R Schlich, M Willems… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE To study expression of the recently identified adipokine dipeptidyl peptidase-4
(DPP4) in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) of patients …

An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease

J Zhong, X Rao, S Rajagopalan - Atherosclerosis, 2013 - Elsevier
The introduction of dipeptidyl peptidase 4 (DPP4) inhibitors for the treatment of Type 2
diabetes acknowledges the fundamental importance of incretin hormones in the regulation …

DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-induced obesity

T Romacho, H Sell, I Indrakusuma… - American Journal …, 2020 - journals.physiology.org
Besides a therapeutic target for type 2 diabetes, dipeptidyl peptidase 4 (DPP4) is an
adipokine potentially upregulated in human obesity. We aimed to explore the role of …

Regulation of dipeptidyl peptidase 4 production in adipocytes by glucose

SS Das, H Hayashi, T Sato, R Yamada… - … syndrome and obesity …, 2014 - Taylor & Francis
Objective Type 1 and 2 diabetes are characterized by elevated blood glucose levels and
increased dipeptidyl peptidase 4 (DPP4) activity levels in the serum. However, previous …

Increased plasma dipeptidyl peptidase-4 (DPP4) activity is an obesity-independent parameter for glycemic deregulation in type 2 diabetes patients

J Sarkar, T Nargis, O Tantia, S Ghosh… - Frontiers in …, 2019 - frontiersin.org
Background: Increase in circulating dipeptidyl peptidase-4 (DPP4) activity and levels has
been reported to associate both with hyperglycemia and obesity. Here we aim to decipher …

Potential effect of DPP-4 inhibitors towards hepatic diseases and associated glucose intolerance

A Sharma, T Virmani, A Sharma… - … and Obesity: Targets …, 2022 - Taylor & Francis
Abstract Dipeptidyl-peptidase-4 (DPP-4) is an enzyme having various properties and
physiological roles in lipid accumulation, resistance to anticancer agents, and immune …

Dipeptidyl peptidase 4 activity is related to body composition, measures of adiposity, and insulin resistance in subjects with excessive adiposity and different degrees …

WS Silva Junior, MGC Souza… - Journal of diabetes …, 2019 - Wiley Online Library
Background. The enzyme dipeptidyl peptidase 4 (DPP4) has been recently recognized as
an adipo‐myokine. However, studies that associate its constitutive activity with body …