Type 1 diabetes develops over many years and is characterized ultimately by the destruction
of insulin-producing pancreatic beta cells by autoreactive T cells. Nonetheless, the role of …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

For unknown reasons, autoimmune diseases such as type 1 diabetes develop after
prolonged periods of inflammation of mononuclear cells in target tissues. Here we show that …

Abstract Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-
mediated destruction of insulin-producing β-cells. Its incidence has increased during the …

In nonobese diabetic (NOD) mice, β–cell reactive T–helper type 1 (Th1) responses develop
spontaneously and gradually spread, creating a cascade of responses that ultimately …

Pancreatic islets of Langerhans are enveloped by peri-islet Schwann cells (pSC), which
express glial fibrillary acidic protein (GFAP) and S100β. pSC-autoreactive T-and B-cell …

The influence of maternally transmitted immunoglobulins on the development of
autoimmune diabetes mellitus in genetically susceptible human progeny remains unknown …

Autoimmune diabetes mellitus in humans is characterized by immunological destruction of
pancreatic beta islet cells. We investigated the circumstances under which CD8+ T cells …

Inflammation is increasingly regarded as a key process underlying metabolic diseases in
obese individuals. In particular, obese adipose tissue shows features characteristic of active …

Abstract Type 1 diabetes (T1D) in non-obese diabetic (NOD) mice may be favored by
immune dysregulation leading to the hyporesponsiveness of regulatory T cells and …