Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents

J Chen, T Wang, S Xu, A Lin, H Yao, W Xie… - European journal of …, 2017 - Elsevier
A novel class of NO-donating protoberberine derivatives were synthesized and initially
evaluated for their anti-hepatocellular carcinoma activities. Most of the compounds exhibited …

Synthesis of β-Carboline-Based N-Heterocyclic Carbenes and Their Antiproliferative and Antimetastatic Activities against Human Breast Cancer Cells

SU Dighe, S Khan, I Soni, P Jain, S Shukla… - Journal of Medicinal …, 2015 - ACS Publications
A series of novel β-carboline-based N-heterocyclic carbenes was prepared via Mannich
reaction between methyl 1-(dimethoxymethyl)-9 H-pyrido [3, 4-b] indole-3-carboxylate …

A new class of diamide scaffold: Design, synthesis and biological evaluation as potent antimitotic agents, tubulin polymerization inhibition and apoptosis inducing …

KO Mohamed, I Zaki, IM El-Deen, MK Abdelhameid - Bioorganic Chemistry, 2019 - Elsevier
A new series of diamide functional compounds has been designed, synthesized and
confirmed by spectroscopic methods and elemental analyses. All the synthesized …

Semicarbazone derivatives bearing phenyl moiety: Synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study

J Ma, X Ni, Y Gao, K Huang, Y Wang, J Liu… - Chemical and …, 2019 - jstage.jst.go.jp
A series of semicarbazone derivatives bearing phenyl moiety were synthesized and
evaluated for the vitro anticancer activities in four human cancer cell lines (human colon …

β-Carbolines as potential anticancer agents

S Aaghaz, K Sharma, R Jain, A Kamal - European Journal of Medicinal …, 2021 - Elsevier
Abstract β-Carbolines are indole alkaloids having a tricyclic pyrido [3, 4-b] indole ring in their
structure. Since the isolation of first β-carboline from Peganum harmala in 1841, the isolation …

Synthesis and cytotoxic evaluation of novel paraconic acid analogs

C Le Floch, E Le Gall, E Léonel, T Martens… - Bioorganic & medicinal …, 2011 - Elsevier
A novel class of 2, 3-tri-and tetrasubstituted γ-butyrolactones analogous to paraconic acids
has been synthesized in one step using a straightforward three-component reaction among …

Synthesis and cytotoxicity evaluation of (tetrahydro-β-carboline)-1, 3, 5-triazine hybrids as anticancer agents

R Kumar, L Gupta, P Pal, S Khan, N Singh… - European journal of …, 2010 - Elsevier
A series of tetrahydro-β-carbolines and 1, 3, 5-triazine hybrids have been synthesized and
evaluated for their cytotoxicity against a panel of eight human cancer cell lines and normal …

Recent trends in the design, synthesis and biological exploration of β-lactams

G Veinberg, I Potorocina… - Current Medicinal …, 2014 - ingentaconnect.com
Since the discovery of penicillin, natural and synthetic β-lactams have aroused great interest
not only as sources of effective antibacterial agents but also as specific inhibitors of …

3-Amide-β-carbolines block the cell cycle by targeting CDK2 and DNA in tumor cells potentially as anti-mitotic agents

D Zhi, Z An, L Li, C Zheng, X Yuan, Y Lan, J Zhang… - Bioorganic …, 2024 - Elsevier
Abstract β-Carboline alkaloids are natural and synthetic products with outstanding antitumor
activity. C 3 substituted and dimerized β-carbolines exert excellent antitumor activity. In the …

Ferrocene appended naphthalimide derivatives: Synthesis, DNA binding, and in vitro cytotoxic activity

DG Jia, JA Zheng, YR Fan, JQ Yu, XL Wu… - Journal of …, 2019 - Elsevier
Three novel ferrocene appended naphthalimide derivatives (2a, 2b and 6) were synthesized
and characterized by IR, 1 H NMR and mass spectroscopies. In electrochemical …