Aims Major depressive disorder (MDD) is a prevalent global mental illness with diverse
underlying causes. Despite the availability of first-line antidepressants, approximately 10 …

Background Treatment-resistant depression (TRD) results in huge healthcare costs and
poor patient clinical outcomes. Most studies have adopted a “candidate mechanism” …

Major depressive disorder (MDD) is a complex illness that involves the interaction of
different brain systems, pathways, and cell types. Past molecular studies of MDD relied on …

Background Major depressive disorder (MDD) is a common mental illness that affects
millions of people worldwide and imposes a heavy burden on individuals, families and …

Disrupted synaptic plasticity is the hallmark of major depressive disorder (MDD), with
accompanying changes at the molecular and cellular levels. Often, the maladaptive …

Astrocytic dysfunction contributes to the molecular pathogenesis of major depressive
disorder (MDD). However, the astrocytic subtype that mainly contributes to MDD etiology …

Abstract Major Depressive Disorder (MDD) is a common psychiatric disorder for which
available medications are often not effective. The high prevalence of MDD and modest …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Depressive disorders are widely debilitating psychiatric disease. Despite the considerable
progress in the field of depression therapy, extensive research spanning many decades has …

Background Motor symptoms are well-characterized in Parkinson's disease (PD). However,
non-motor symptoms, such as depression, are commonly observed and can appear up to 10 …