Introduction Neuropeptides arginine-vasopressin (AVP), apelin (APL), and stromal-derived
factor-1α (SDF-1α) are involved in the dysfunction of the corticotropic axis observed in septic …

Introduction Sepsis-induced acute lung injury (ALI) has been reported to have a higher case
fatality rate than other causes of ALI. However, differences in the severity of illness in septic …

Introduction Sepsis and severe sepsis are asociated with high hospital mortality. Little is
known about the occurrence of sepsis in general hospital populations. The goal of the …

Introduction A rational use of antibiotics is of paramount importance in order to prevent the
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …

Introduction The current shortage of accurate and readily available, validated biomarkers of
disease severity in sepsis is an important limitation when attempting to stratify patients into …

Background Sepsis is a leading cause of preventable death around the world. Population-
based estimation of sepsis incidence is lacking in China. In this study, we aimed to estimate …

Introduction Bacteremia is recognized as a critical condition that influences the outcome of
sepsis. Although large-scale surveillance studies of bacterial species causing bacteremia …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

Introduction Although major changes of the immune system have been described in sepsis,
it has never been studied whether these may differ in relation to the type of underlying …

Abstract Introduction Higher compliance with Surviving Sepsis Campaign (SSC)
recommendations has been associated with lower mortality. The authors evaluate …