Introduction Sepsis is responsible for important alterations in the pharmacokinetics of
antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in …

Background Antibiotics are commonly administered to hospitalized patients with infiltrates
for possible bacterial pneumonia, often leading to unnecessary treatment and increasing the …

Background Treatment of severe sepsis is expensive, often encompassing a number of
discretionary modalities. The objective of the present study was to assess intercenter …

Background Early administration of appropriate antimicrobials has been correlated with a
better prognosis in patients with bacteremia, but the optimum timing of early antibiotic …

Background The aim of the present study was to evaluate the C-reactive protein level, the
body temperature and the white cell count in patients after prescription of antibiotics in order …

Introduction Host immunity should play a principal role in determining both the outcome and
recovery of patients with sepsis that originated from a microbial infection. Quantification of …

Methods In a cohort study at a tertiary-care medical-surgical ICU with a total of 35 acute-care
beds, we included all ICU patients with the diagnosis of severe sepsis and septic shock …

Introduction We evaluated the accuracy of hospital discharge diagnoses in the identification
of community-acquired sepsis and severe sepsis. Methods We reviewed 379 serious …

Introduction Costs are one of the factors determining physicians' choice of medication to
treat patients in specific situations. However, usually only the drug acquisition costs are …

Introduction Critically ill patients and families rely upon physicians to provide estimates of
prognosis and recommendations for care. Little is known about patient and clinician factors …