Clinically relevant pharmacokinetic knowledge on antibiotic dosing among intensive care professionals is insufficient: a cross-sectional study
Background Antibiotic exposure in intensive care patients with sepsis is frequently
inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the …
inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the …
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study
F Bloos, D Thomas-Rüddel, H Rüddel, C Engel… - Critical care, 2014 - Springer
Introduction Current sepsis guidelines recommend antimicrobial treatment (AT) within one
hour after onset of sepsis-related organ dysfunction (OD) and surgical source control within …
hour after onset of sepsis-related organ dysfunction (OD) and surgical source control within …
An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial
RS Nannan Panday, EMJ Lammers, N Alam… - Critical Care, 2019 - Springer
Background Sepsis remains one of the most important causes of morbidity and mortality
worldwide. In approximately 30–50% of cases of suspected sepsis, no pathogen is isolated …
worldwide. In approximately 30–50% of cases of suspected sepsis, no pathogen is isolated …
Characteristics and outcomes of culture-negative versus culture-positive severe sepsis
Introduction Culture-negative sepsis is a common but relatively understudied condition. The
aim of this study was to compare the characteristics and outcomes of culture-negative versus …
aim of this study was to compare the characteristics and outcomes of culture-negative versus …
Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: a pilot …
M Girardis, L Rinaldi, L Donno, M Marietta… - Critical Care, 2009 - Springer
Introduction The application in clinical practice of evidence-based guidelines for the
management of patients with severe sepsis/septic shock is still poor in the emergency …
management of patients with severe sepsis/septic shock is still poor in the emergency …
The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study
JP Quenot, C Binquet, F Kara, O Martinet, F Ganster… - Critical care, 2013 - Springer
Introduction To provide up-to-date information on the prognostic factors associated with 28-
day mortality in a cohort of septic shock patients in intensive care units (ICUs). Methods …
day mortality in a cohort of septic shock patients in intensive care units (ICUs). Methods …
Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized …
H Rüddel, DO Thomas-Rüddel, K Reinhart, F Bach… - Critical Care, 2022 - Springer
Background Timely antimicrobial treatment and source control are strongly recommended
by sepsis guidelines, however, their impact on clinical outcomes is uncertain. Methods We …
by sepsis guidelines, however, their impact on clinical outcomes is uncertain. Methods We …
Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis
K Marquet, A Liesenborgs, J Bergs, A Vleugels… - Critical care, 2015 - Springer
Introduction The aims of this study were to explore the incidence of in-hospital inappropriate
empiric antibiotic use in patients with severe infection and to identify its relationship with …
empiric antibiotic use in patients with severe infection and to identify its relationship with …
Hospital-onset sepsis and community-onset sepsis in critical care units in Japan: a retrospective cohort study based on a Japanese administrative claims database
M Tonai, A Shiraishi, T Karumai, A Endo, H Kobayashi… - Critical Care, 2022 - Springer
Background Hospital-and community-onset sepsis are significant sepsis subgroups.
Japanese data comparing these subgroups are limited. This study aimed to describe the …
Japanese data comparing these subgroups are limited. This study aimed to describe the …
One-year hospital readmission for recurrent sepsis: associated risk factors and impact on 1-year mortality—a French nationwide study
F Pandolfi, C Brun-Buisson, D Guillemot, L Watier - Critical Care, 2022 - Springer
Background Sepsis is a complex health condition, leading to long-term morbidity and
mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid-and …
mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid-and …