Background Trends in the incidence and outcomes of sepsis using a Japanese nationwide
database were investigated. Methods This was a retrospective cohort study. Adult patients …

Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

Introduction Delays in adequate antimicrobial treatment contribute to high cost and mortality
in sepsis. Polymerase chain reaction (PCR) assays are used alongside conventional …

Background Socioeconomic variables impact health outcomes but have rarely been
evaluated in critical illness. Low-and middle-income countries bear the highest burden of …

Although multiple studies of acute myocardial infarction, trauma, and stroke have been
translated into improved outcomes by applying diagnosis and therapy at the most proximal …

Introduction Recent evidence suggests that early, aggressive resuscitation in patients with
septic shock reduces mortality. The objective of this survey was to characterize reported …

Background Nighttime hospital admission is often associated with increased mortality risk in
various diseases. This study investigated compliance rates with the Surviving Sepsis …

Introduction Prompt treatment of severe sepsis in the Emergency Department reduces
deaths, but the role of prehospital fluid resuscitation is unknown. We sought to determine the …

Background Rapid detection, early resuscitation, and appropriate antibiotic use are crucial
for sepsis care. Accurate identification of the site of infection may facilitate a timely provision …

Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The
heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality …