Mechanical injury polarizes skin dendritic cells to elicit a TH2 response by inducing cutaneous thymic stromal lymphopoietin expression
MK Oyoshi, RP Larson, SF Ziegler, RS Geha - Journal of allergy and clinical …, 2010 - Elsevier
BACKGROUND: Atopic dermatitis is characterized by scratching and by TH2-dominated
immune response to cutaneously introduced antigens. Antigen application to skin …
immune response to cutaneously introduced antigens. Antigen application to skin …
Cutting Edge: Identification of the Thymic Stromal Lymphopoietin–Responsive Dendritic Cell Subset Critical for Initiation of Type 2 Contact Hypersensitivity
M Kitajima, SF Ziegler - The Journal of Immunology, 2013 - journals.aai.org
The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the initiation and
progression of allergic inflammation through its ability to activate dendritic cells (DCs) …
progression of allergic inflammation through its ability to activate dendritic cells (DCs) …
Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses
RP Larson, SC Zimmerli, MR Comeau… - The Journal of …, 2010 - journals.aai.org
Thymic stromal lymphopoietin (TSLP) is an IL-7–related cytokine, produced by epithelial
cells, that has been linked to atopic dermatitis and asthma; however, it remains unclear how …
cells, that has been linked to atopic dermatitis and asthma; however, it remains unclear how …
TSLP acts on infiltrating effector T cells to drive allergic skin inflammation
R He, MK Oyoshi, L Garibyan… - Proceedings of the …, 2008 - National Acad Sciences
Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including
keratinocytes, and is important in allergic inflammation. Allergic skin inflammation elicited by …
keratinocytes, and is important in allergic inflammation. Allergic skin inflammation elicited by …
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
V Soumelis, PA Reche, H Kanzler, W Yuan… - Nature …, 2002 - nature.com
Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2
(TH2)-type allergic inflammation is not known. We show here that human thymic stromal …
(TH2)-type allergic inflammation is not known. We show here that human thymic stromal …
Cutting edge: proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes
SI Bogiatzi, I Fernandez, JC Bichet… - The Journal of …, 2007 - journals.aai.org
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that strongly
activates dendritic cells (DC) and can initiate allergic inflammation. The factors inducing the …
activates dendritic cells (DC) and can initiate allergic inflammation. The factors inducing the …
Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells
S Ochiai, F Jagot, RL Kyle, E Hyde… - Proceedings of the …, 2018 - National Acad Sciences
T helper 2 (Th2) cells are pivotal in the development of allergy. Allergen exposure primes IL-
4+ Th2 cells in lymph node, but production of effector cytokines including IL-5 and IL-13 is …
4+ Th2 cells in lymph node, but production of effector cytokines including IL-5 and IL-13 is …
Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells
S Ebner, M Forstner, YH Wang, D Wolfram… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Thymic stromal lymphopoietin (TSLP) endows human CD11c+ dendritic
cells (DCs) from peripheral blood with the capacity to induce proallergic T cells. TSLP is …
cells (DCs) from peripheral blood with the capacity to induce proallergic T cells. TSLP is …
[HTML][HTML] TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice
JM Leyva-Castillo, P Hener, H Jiang, M Li - Journal of Investigative …, 2013 - Elsevier
Atopic dermatitis often precedes the development of asthma, a phenomenon known as
“atopic march”. An important role of allergen sensitization developed through barrier …
“atopic march”. An important role of allergen sensitization developed through barrier …
Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells
M Gilliet, V Soumelis, N Watanabe… - The Journal of …, 2003 - rupress.org
Human thymic stromal lymphopoietin (TSLP) is a novel epithelial cell–derived cytokine,
which induces dendritic cell (DC)-mediated CD4+ T cell responses with a proallergic …
which induces dendritic cell (DC)-mediated CD4+ T cell responses with a proallergic …