Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease

S Yazid, PJ Gardner, L Carvalho, CJ Chu… - Journal of …, 2015 - Elsevier
Abstract Annexin-A1 (Anx-A1) is an endogenous anti-inflammatory molecule and while
described as a repressor of innate immune responses, the role of Anx-A1 in adaptive …

Deficiency of annexin A1 in CD4+ T cells exacerbates T cell–dependent inflammation

YH Yang, W Song, JA Deane, W Kao… - The Journal of …, 2013 - journals.aai.org
Abstract Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule.
However, its effects on the adaptive immune response and, in particular, on T cells remain …

Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection

N Paschalidis, A Huggins, NJ Rowbotham… - Cell Cycle, 2010 - Taylor & Francis
We have recently shown that endogenous Annexin-A1 (AnxA1) plays a homeostatic
regulatory role in mature T cells by modulating the strength of TCR signaling. In this study …

Annexin A6 regulates interleukin‐2‐mediated T‐cell proliferation

R Cornely, AH Pollock, C Rentero… - Immunology and cell …, 2016 - Wiley Online Library
Annexin A6 (AnxA6) has been implicated in cell signalling by contributing to the
organisation of the plasma membrane. Here we examined whether AnxA6 regulates …

Annexin-1 modulates T-cell activation and differentiation

F D'Acquisto, A Merghani, E Lecona, G Rosignoli… - Blood, 2007 - ashpublications.org
Annexin-1 is an anti-inflammatory protein that plays an important homeostatic role in innate
immunity; however, its potential actions in the modulation of adaptive immunity have never …

Reduced annexin A1 expression associates with disease severity and inflammation in multiple sclerosis patients

A Colamatteo, E Maggioli… - The Journal of …, 2019 - journals.aai.org
Chronic neuroinflammation is a key pathological hallmark of multiple sclerosis (MS) that
suggests that resolution of inflammation by specialized proresolving molecules is …

More than just innate affairs–on the role of annexins in adaptive immunity

H Weyd - Biological Chemistry, 2016 - degruyter.com
In more than 30 years of research annexins have been demonstrated to regulate immune
responses. The prototype member of this family, annexin (Anx) A1, has been widely …

Annexin‐A1: the culprit or the solution?

L Kelly, S McGrath, L Rodgers, K McCall… - …, 2022 - Wiley Online Library
Annexin‐A1 has a well‐defined anti‐inflammatory role in the innate immune system, but its
function in adaptive immunity remains controversial. This glucocorticoid‐induced protein has …

The tolerogenic function of annexins on apoptotic cells is mediated by the annexin core domain

B Linke, L Abeler-Dörner, V Jahndel, A Kurz… - The Journal of …, 2015 - journals.aai.org
Immunological tolerance is constantly being maintained in the periphery by dendritic cells
processing material from apoptotic cells (ACs) in the steady-state. Although research has …

The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti‐inflammatory phenotype

B Frey, LE Munoz, F Pausch, R Sieber… - Journal of cellular …, 2009 - Wiley Online Library
Proteins of the annexin family bind to phospholipids in a Ca2+ dependent manner. The
exposure of phosphatidylserine (PS) by apoptotic as well as necrotic cells is one major eat …