Sixty years ago the clinical neurophysiology of epilepsy had progressed to the stage that it
posed questions that could be addressed by major advances in cellular electrophysiology …

Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-
century, that significant progress has been made in our basic understanding of the epileptic …

As one of the most common neurological disorders, epilepsy has devastating behavioral,
social, and occupational consequences and is associated with accumulating brain damage …

Epilepsy is a complex disease with diverse clinical characteristics that preclude a singular
mechanism. One way to gain insight into potential mechanisms is to reduce the features of …

This chapter reviews the cellular and synaptic basis for focal and generalized seizure
generation with an emphasis on ion channels and synaptic physiology. This background is …

Over the last 15 years, neurobiologists have begun to unravel the cellular mechanisms that
underlie epileptiform activity. Such investigations have two main objectives:(I) to develop …

Seizures are one of the most common neurologic disorders affecting children. As many as
5% of children experience a seizure during childhood. Although many epilepsies, especially …

Treatment options for epilepsy, especially using antiepileptic drugs, have increased
substantially in the past five years. Since 1993, four novel antiepileptic drugs have been …

▪ Abstract The highly interconnected networks of the mammalian forebrain can generate a
wide variety of synchronized activities, including those underlying epileptic seizures, which …

Epilepsy is a complex disease, characterized by the repeated occurrence of bursts of
electrical activity (seizures) in specific brain areas. The behavioral outcome of seizure …