I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between
hepatic glucose production and glucose utilization by the major insulin-dependent tissues …

The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …

Following the discovery of insulin, it took the rest of the twentieth century to understand how
this hormone regulates intracellular metabolism. What are the main discoveries that led to …

The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …

A continuous supply of glucose is necessary to ensure proper function and survival of all
organs. Plasma glucose levels are thus maintained in a narrow range around 5 mM, which …

In mammals, insulin is the principal hormone controlling blood glucose and acts by
stimulating glucose influx and metabolism in muscle and adipocytes and inhibiting …

A significant stress faced by all animals is the unpredictable cycle of feeding and then
starvation that ensues between meals. Humans solve this problem by storing nutrients in …

We have achieved significant progress in understanding the central role of the insulin
receptor in an increasingly complicated web of intracellular signal transduction leading to …

Insulin is a key hormone regulating the control of metabolism and the maintenance of
normoglycaemia and normolipidaemia. Insulin acts by binding to its cell surface receptor …

Association for recognizing our continued work on the biochemical mechanism of insulin
action by this award. I would like to share my perspective of the evolution of the current …