Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men

J Lieberz, D Scheele, FB Spengler… - …, 2020 - nature.com
Accumulating evidence suggests that intranasal oxytocin (OXT; 24 IU) reduces amygdala
responses to fear-related stimuli in men, while exerting inverse effects in women. However …

[HTML][HTML] Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within …

DS Quintana, LT Westlye, D Alnæs, ØG Rustan… - …, 2016 - Elsevier
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social
behavior and cognition and what is the optimal dose for OT response. To better understand …

Effects of intranasal oxytocin on emotional face processing in women

G Domes, A Lischke, C Berger, A Grossmann… - …, 2010 - Elsevier
The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity
to social and emotional stimuli in healthy men. The present study aimed to investigate the …

A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

J Kou, Y Zhang, F Zhou, C Sindermann… - Psychological …, 2022 - cambridge.org
BackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …

Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity

FB Spengler, J Schultz, D Scheele, M Essel, W Maier… - Biological …, 2017 - Elsevier
Background Current neuroimaging perspectives on a variety of mental disorders emphasize
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …

[HTML][HTML] Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients

SBJ Koch, M van Zuiden, L Nawijn, JL Frijling… - …, 2016 - nature.com
Post-traumatic stress disorder (PTSD) is a disabling psychiatric disorder. As a substantial
part of PTSD patients responds poorly to currently available psychotherapies …

Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces

L Luo, B Becker, Y Geng, Z Zhao, S Gao, W Zhao… - Neuroimage, 2017 - Elsevier
In line with animal models indicating sexually dimorphic effects of oxytocin (OXT) on social-
emotional processing, a growing number of OXT-administration studies in humans have …

Oxytocin attenuates amygdala responses to emotional faces regardless of valence

G Domes, M Heinrichs, J Gläscher, C Büchel… - Biological …, 2007 - Elsevier
BACKGROUND: Oxytocin is known to reduce anxiety and stress in social interactions as
well as to modulate approach behavior. Recent studies suggest that the amygdala might be …

Oxytocin increases amygdala reactivity to threatening scenes in females

A Lischke, M Gamer, C Berger, A Grossmann… - …, 2012 - Elsevier
The neuropeptide oxytocin (OT) is well known for its profound effects on social behavior,
which appear to be mediated by an OT-dependent modulation of amygdala activity in the …

[HTML][HTML] In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing

J Kou, C Lan, Y Zhang, Q Wang, F Zhou, Z Zhao… - Translational …, 2021 - nature.com
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …