The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is
responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated …

Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia
(ATL), a rapidly progressing, clonal malignancy of CD4+ T lymphocytes. Fewer than one in …

The virally encoded oncoprotein Tax has been implicated in HTLV-1-mediated cellular
transformation. The exact mechanism by which this protein contributes to the oncogenic …

The importance of maintaining genomic stability is evidenced by the fact that transformed
cells often contain a variety of chromosomal abnormalities such as euploidy, translocations …

HTLV-1 is the etiological agent of adult T-cell leukemia (ATL), the neurological syndrome
TSP/HAM and certain other clinical disorders. The viral Tax protein is considered to play a …

To achieve cellular transformation, most oncogenic retroviruses use transduction by proto-
oncogene capture or insertional mutagenesis, whereby provirus integration disrupts …

The human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell
leukemia (ATL), an aggressive CD4-positive T-cell neoplasia. The HTLV-1 proto-oncogene …

Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia
(ATL) and various human myopathies/neuropathies. HTLV-I encodes a 40 kDa …

The HTLV Tax protein is crucial for viral replication and for initiating malignant
transformation leading to the development of adult T-cell leukemia. Tax has been shown to …

Human T-cell leukemia virus type-1 is the causative agent for adult T-cell leukemia. Previous
research has established that the viral oncoprotein Tax mediates the transformation process …