Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells
K Machida, KTH Cheng, N Pavio, VMH Sung… - Journal of …, 2005 - Am Soc Microbiol
Hepatitis C virus (HCV) is one of the leading causes of chronic liver diseases and B-
lymphocyte proliferative disorders, including mixed cryoglobulinemia and B-cell lymphoma …
lymphocyte proliferative disorders, including mixed cryoglobulinemia and B-cell lymphoma …
Activation of naive B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
D Rosa, G Saletti, E De Gregorio… - Proceedings of the …, 2005 - National Acad Sciences
Infection with hepatitis C virus (HCV), a leading cause of chronic liver diseases, can
associate with B lymphocyte proliferative disorders, such as mixed cryoglobulinemia and …
associate with B lymphocyte proliferative disorders, such as mixed cryoglobulinemia and …
Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein
Hepatitis C virus (HCV) often causes persistent infection despite the presence of neutralizing
antibodies against the virus in the sera of hepatitis C patients. HCV infects both hepatocytes …
antibodies against the virus in the sera of hepatitis C patients. HCV infects both hepatocytes …
Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co‐stimulatory signal for human T cells
Chronic hepatitis C virus (HCV) infection frequently develops into liver disease and is
accompanied by extra‐hepatic autoimmune manifestations. The tetraspanin CD81 is a …
accompanied by extra‐hepatic autoimmune manifestations. The tetraspanin CD81 is a …
Binding of hepatitis C virus to CD81
Chronic hepatitis C virus (HCV) infection occurs in about 3 percent of the world's population
and is a major cause of liver disease. HCV infection is also associated with …
and is a major cause of liver disease. HCV infection is also associated with …
Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
CTK Tseng, GR Klimpel - The Journal of experimental medicine, 2002 - rupress.org
Infection with hepatitis C virus (HCV) is a leading cause of chronic liver disease worldwide.
Little is known about how this virus is able to persist or whether this persistence might be …
Little is known about how this virus is able to persist or whether this persistence might be …
Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection
E Zuckerman, A Kessel, G Slobodin, E Sabo… - Journal of …, 2003 - Am Soc Microbiol
Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation. Recently, CD81 was identified as an HCV receptor on B …
cell lymphoproliferation. Recently, CD81 was identified as an HCV receptor on B …
CD81-dependent binding of hepatitis C virus E1E2 heterodimers
L Cocquerel, CC Kuo, J Dubuisson, S Levy - Journal of virology, 2003 - Am Soc Microbiol
Hepatitis C virus (HCV) is the leading cause of chronic liver disease worldwide. HCV is also
the major cause of mixed cryoglobulinemia, a B-lymphocyte proliferative disorder. Direct …
the major cause of mixed cryoglobulinemia, a B-lymphocyte proliferative disorder. Direct …
Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection
E Zuckerman, G Slobodin, A Kessel… - Clinical & …, 2002 - academic.oup.com
Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation evolving to an overt lymphoma. Recently, CD81 was identified as an …
cell lymphoproliferation evolving to an overt lymphoma. Recently, CD81 was identified as an …
[HTML][HTML] Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement
Z Chen, Y Zhu, Y Ren, Y Tong, X Hua, F Zhu… - PLoS …, 2011 - journals.plos.org
HCV infection is often associated with B-cell regulatory control disturbance and delayed
appearance of neutralizing antibodies. CD81 is a cellular receptor for HCV and can bind to …
appearance of neutralizing antibodies. CD81 is a cellular receptor for HCV and can bind to …