ContextEpidemiological studies have implicated the inducible form of cyclooxygenase (COX-
2) in the pathogenesis of colorectal cancer; however, its role is not fully understood …

Purpose: Recent studies have shown that cyclooxygenase (Cox)-2 may be involved in
colorectal carcinogenesis. We aimed to determine whether Cox-2 expression in itself can …

OBJECTIVE: We aimed to investigate the associations of cyclooxygenase-2 (COX-2) with
pathological features and survival in patients with colorectal cancer. METHODS: The …

BACKGROUND Experimental, clinical, and epidemiological studies have implicated
mitogenic metabolites of arachidonic acid such as prostaglandin E2 (PGE2) in colorectal …

The role of cyclooxygenase-2 (COX-2) in tumor neovascularization of human colorectal
carcinoma is yet to be delineated. One hundred colorectal carcinoma specimens were …

Abstract Purpose: Cyclooxygenase-2 (COX-2; PTGS2) is considered to play an important
role in colorectal carcinogenesis and is often up-regulated in colon cancers. However …

Abstract Background/Aims: Several clinical, epidemiological, and animal studies indicate
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …

Non‐steroidal anti‐inflammatory drugs are chemopreventive for colorectal cancer. This
effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX‐2) …

Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs
(NSAIDs), known to inhibit cyclooxygenase (COX), reduce the risk of colorectal cancer. COX …

Recent epidemiologic studies have shown a 40–50% reduction in mortality from colorectal
cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis …