Costunolide protects against alcohol‐induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro

J Mao, H Zhan, F Meng, G Wang, D Huang… - Phytotherapy …, 2022 - Wiley Online Library
Costunolide (cos) derived from the roots of Dolomiaea souliei (Franch.), which belongs to
the Dolomiaea genus in the family Compositae, exert the anti‐inebriation effect mainly by …

[HTML][HTML] Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice

J Mao, M Yi, R Wang, Y Huang, M Chen - Frontiers in Pharmacology, 2018 - frontiersin.org
Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to
exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of …

Costunolide protects lipopolysaccharide/d-galactosamine–induced acute liver injury in mice by inhibiting NF-κB signaling pathway

Y Wang, X Zhang, L Zhao, M Shi, Z Wei, Z Yang… - Journal of Surgical …, 2017 - Elsevier
Background Costunolide, a well-known sesquiterpene lactone, has been reported to have
anti-inflammatory and anti-oxidative effects. Methods In this study, we aim to investigate the …

[HTML][HTML] Triterpenoids Extracted From Antrodia cinnamomea Mycelia Attenuate Acute Alcohol-Induced Liver Injury in C57BL/6 Mice via Suppression Inflammatory …

Y Liu, Z Wang, F Kong, L Teng, X Zheng, X Liu… - Frontiers in …, 2020 - frontiersin.org
Excessive alcohol consumption causes liver injury–induced mortality. Here we
systematically analyzed the structure of triterpenoids extracted from Antrodia cinnamomea …

Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation

H Zheng, Y Chen, J Zhang, L Wang, Z Jin… - Chemico-Biological …, 2016 - Elsevier
The aim of the present study was to evaluate the anti-ulcerogenic activity of costunolide (Co)
and dehydrocostuslactone (De) on ethanol-induced gastric ulcer in mice and to elucidate …

Echinacoside from Cistanche tubulosa ameliorates alcohol‐induced liver injury and oxidative stress by targeting Nrf2

Y Ding, Y Zhang, Z Wang, F Zeng, Q Zhen… - The FASEB …, 2023 - Wiley Online Library
Abstract Cistanche tubulosa (Schrenk) Wight, named Guan hua Rou Cong‐Rong in
Chinese, is a traditional plant with liver, kidney, and intestine protective effects …

Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway

S Wu, F Wen, X Zhong, W Du, M Chen… - Annals of Medicine, 2023 - Taylor & Francis
Abstract Purpose Astragaloside IV (AS-IV) is a natural saponin substance extracted from the
plant Radix Astragali with anti-inflammatory, antioxidant, anti-apoptotic, and liver-protecting …

[HTML][HTML] Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways

A Nagappan, JH Kim, DY Jung, MH Jung - International journal of …, 2019 - mdpi.com
Cryptotanshinone (CT), a diterpene that is isolated from Salvia miltiorrhiza Bunge, exhibits
anti-cancer, anti-oxidative, anti-fibrosis, and anti-inflammatory properties. Here, we …

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF‐β1/Smad2, NF‐κB, and AMPK signaling …

G Liu, Z Cui, X Gao, H Liu, L Wang, J Gong… - Phytotherapy …, 2021 - Wiley Online Library
Hawthorn (Crataegus pinnatifida Bunge. var. major) is an edible and medicinal fruit that is
very common in food and traditional Chinese medicine. Corosolic acid (CA), a pentacyclic …

[HTML][HTML] Costunolide alleviated DDC induced ductular reaction and inflammatory response in murine model of cholestatic liver disease

J Hao, X Shen, K Lu, Y Xu, Y Chen, J Liu… - Journal of Traditional …, 2023 - Elsevier
Purpose Cholestatic liver diseases are groups of hepatobiliary diseases without curative
drug-based therapy options. Regulation of bile acid (BA) metabolism, hepatoperiductal …