Protection against cellular stress from various sources, such as nutritional, physical,
pathogenic, or oncogenic, results in the induction of both intrinsic and extrinsic cellular …

The mechanisms that regulate NK cell function as a first line of defense against infection and
transformation have exceeded our expectations in terms of their sophistication and …

Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell
surface ligands that are induced preferentially or exclusively on these cells. These ligands …

With an array of activating and inhibitory receptors, natural killer (NK) cells can specifically
eradicate infected and transformed cells. Target cell killing is achieved through directed …

Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic
development, growth, and metastatic dissemination in a process called cancer …

Natural killer cells were named after their ability to mediate spontaneous cytotoxicity during
innate immune responses. However, it has become clear in recent years that they play an …

Pathogenic and oncogenic insults result in the induction of intrinsic defense mechanisms
such as cell-death pathways and senescence, and extrinsic pathways that mobilize immune …

Natural killer (NK) cells are important for early immune responses to viral infections and
cancer. Upon activation, NK cells secrete cytokines and chemokines, and kill sensitive target …

In light of their role in the immune response against tumors and viruses, natural killer (NK)
cells represent a promising target for immunotherapy. Before this target is reached, the …

Initially described as effectors of natural cytotoxicity and critical players for the control of viral
infections and tumor growth, recent investigations unraveled more widespread functions for …