Intestinal epithelial cells form a tight barrier to act as selective physical barriers, repelling
hostile substances. Tumor necrosis factor-α (TNF-α) is a well characterized pro-inflammatory …

Impaired intestinal barrier function is one of the critical issues in inflammatory bowel
diseases. The aim of this study is to investigate muscarinic cholinoceptor (mAChR) …

Impairment of epithelial barrier is observed in various intestinal disorders including
inflammatory bowel diseases (IBD). Numerous factors may cause temporary damage of the …

Background & Aims: Tumor necrosis factor (TNF) plays a critical role in intestinal disease. In
intestinal epithelia, TNF causes tight junction disruption and epithelial barrier loss by up …

PURPOSE: The aim of this study was to investigate the signaling mechanisms surrounding
changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced …

Abstract Background/Aims: Although proinflammatory cytokine–induced disruption of
intestinal epithelial barrier integrity is associated with intestinal inflammatory disease …

TNF-α plays a central role in the intestinal inflammation of various inflammatory disorders
including Crohn's disease (CD). TNF-α-induced increase in intestinal epithelial tight junction …

Altered mucosal integrity and increased cytokine production, including tumor necrosis factor
(TNF), are the hallmarks of inflammatory bowel disease (IBD). In this study, we addressed …

Intestinal barrier dysfunction characterized by the functional loss of the intestinal epithelium's
tight junction (TJ) barrier is a key factor in the pathogenesis of ulcerative colitis (UC) …

A TNF-α-induced increase in intestinal epithelial tight junction (TJ) permeability has been
proposed to be an important proinflammatory mechanism contributing to intestinal …