The complement inflammatory cascade is an essential component of the phylogenetically
ancient innate immune response and is crucial to our natural ability to ward off infection …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

Complement is an important component of the innate immune response with the capacity to
recognize and clear infectious challenges that invade the CNS through a damaged blood …

The spectrum of inflammatory diseases is nowadays considered to include diverse diseases
of the central nervous system (CNS). Current evidence suggests that syndromes such as …

Increasing evidence suggests that inflammatory and immune components in brain are
important in Alzheimer's disease (AD) and anti-inflammatory and immunotherapeutic …

Classic innate immune signaling pathways provide most of the immune response in the
brain. This response activates many of the canonical signaling mechanisms identified in …

The innate immune system and notably the complement (C) system play important roles in
host defense to recognise and kill deleterious invaders or toxic entities, but activation at …

The immune response after brain injury is highly complex and involves both local and
systemic events at the cellular and molecular level. It is associated to a dramatic over …

While the mechanisms underlying the functions of the complement system in the central
nervous system (CNS) and systemically, namely opsonization, chemotaxis, membrane lysis …