Background: Drug-induced liver injury (DILI), represented by acetaminophen (APAP), is a
common cause of acute liver failure in clinics. Paeoniflorin (PF) has been proven to …

Background Drug-induced liver injury (DILI) is gradually becoming a common global
problem that causes acute liver failure, especially in acute hepatic damage caused by …

The common analgesic acetaminophen (N-acetyl-p-aminophenol, APAP) is non-toxic to the
liver at therapeutic doses. However, an overdose of APAP can lead to APAP-induced liver …

Acetaminophen (APAP) is a widely used over-the-counter drug for antipyretic and analgesic,
but an overdose will induce acute liver injury. APAP hepatotoxicity has been the most …

Background: Paeoniflorin (PF), the major active compound isolated from the roots of
Paeonia lactiflora Pall., has been used in the treatment of severe hepatic diseases for …

Abstract Ethnopharmacological relevance Paeonia lactiflora Pall.(PLP), a traditional
Chinese medicine, is recognized for its antioxidative and anti-apoptotic properties. Despite …

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. The purpose of this study was to investigate whether paeonol protected against …

The pathological mechanism of cholestatic hepatic injury is associated with oxidative stress,
hepatocyte inflammation, and dysregulation of hepatocyte transporters. Paeonia lactiflora …

Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses
numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and …

Abstract Background Cirsii Japonici Herba Carbonisata (Dajitan in Chinese) has been used
to treat liver disorders in Asian countries. Pectolinarigenin (PEC), an abundant constituent in …