Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
Background—Apelin is among the most potent stimulators of cardiac contractility known.
However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) …
However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) …
The apelin–APJ system in heart failure: pathophysiologic relevance and therapeutic potential
AG Japp, DE Newby - Biochemical pharmacology, 2008 - Elsevier
Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor,
APJ. This novel peptidic signalling pathway is widely represented in the heart and …
APJ. This novel peptidic signalling pathway is widely represented in the heart and …
The role of apelin in cardiovascular function and heart failure
B Chandrasekaran, O Dar… - European journal of heart …, 2008 - Wiley Online Library
Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the
angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …
angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …
Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure
KS Chong, RS Gardner, JJ Morton… - European journal of …, 2006 - Wiley Online Library
Background: Apelin, the novel endogenous ligand for the G‐protein‐coupled receptor APJ,
has shown positive inotropic, vasodilatory and diuretic properties in animal studies …
has shown positive inotropic, vasodilatory and diuretic properties in animal studies …
The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
EA Ashley, J Powers, M Chen, R Kundu… - Cardiovascular …, 2005 - academic.oup.com
Objective: The endogenous peptide apelin is differentially regulated in cardiovascular
disease but the nature of its role in cardiac function remains unclear. Methods: We …
disease but the nature of its role in cardiac function remains unclear. Methods: We …
Translational promise of the apelin–APJ system
G Barnes, AG Japp, DE Newby - Heart, 2010 - heart.bmj.com
Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key
hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with …
hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with …
Down-regulation of cardiac apelin system in hypertrophied and failing hearts: possible role of angiotensin II–angiotensin type 1 receptor system
Y Iwanaga, Y Kihara, H Takenaka, T Kita - Journal of molecular and cellular …, 2006 - Elsevier
Cardiac apelin has recently been suggested to contribute to the pathophysiology of heart
failure (HF) in humans. In animal experiments, its infusion acutely improved systolic as well …
failure (HF) in humans. In animal experiments, its infusion acutely improved systolic as well …
Apelin: a novel neurohumoral modulator of the cardiovascular system. Pathophysiologic importance and potential use as a therapeutic target
I Falcão-Pires, AF Leite-Moreira - Revista portuguesa de …, 2005 - pubmed.ncbi.nlm.nih.gov
Apelin is a recently discovered vasoactive peptide that has been demonstrated to be the
endogenous ligand of the APJ receptor. It was named'apelin'after APJ endogenous ligand …
endogenous ligand of the APJ receptor. It was named'apelin'after APJ endogenous ligand …
Modulation of the apelin/APJ system in heart failure and atherosclerosis in man
SL Pitkin, JJ Maguire, RE Kuc… - British journal of …, 2010 - Wiley Online Library
Background and purpose: The aim of this study was to determine whether the apelin/APJ
system is altered in human cardiovascular disease by investigating whether the expression …
system is altered in human cardiovascular disease by investigating whether the expression …
Endogenous regulation of cardiovascular function by apelin-APJ
DN Charo, M Ho, G Fajardo… - American Journal …, 2009 - journals.physiology.org
Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …
including the potent activation of cardiac contraction. However, the role of the endogenous …
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