Accumulating evidence indicates that progestins are involved in controlling mammary gland
tumorigenesis. Here, we assessed the molecular mechanisms of progestin action in breast …

Progesterone receptors (PR) are useful prognostic indicators of breast cancers likely to
respond to anti-estrogen receptor (ER) therapies. However, the role of progesterone …

Progestins induce proliferation of breast cancer cells and are implicated in the development
of breast cancer. The effects of progestins are mediated by progesterone receptors (PRs) …

Progesterone receptor (PR) isoforms are dual functioning steroid hormone receptors,
capable of activation of target gene transcription, and rapid stimulation of membrane …

Progesterone (P) regulates proliferation and differentiation in the normal mammary gland in
mouse, rat and human. Progesterone has also been implicated in the etiology and …

Estrogen treatment of MCF-7 human breast cancer cells allows the reinitiation of
synchronous cell cycle progression in antiestrogen-arrested cells. Here, we report that …

Synthetic progesterone used in contraception drugs (progestins) can promote breast cancer
growth, but the mechanisms involved are unknown. Moreover, it remains unclear whether …

Multiple laboratories have investigated progesterone receptor (PR) involvement in breast
cancer cell cycle progression. There is now a growing body of evidence demonstrating …

Progesterone plays an important, if not controversial, role in mammary epithelial cell
proliferation and differentiation. Evidence supports that progesterone promotes rodent …

Progesterone and progesterone receptors (PR) have a storied albeit controversial history in
breast cancers. As endocrine therapies for breast cancer progressed through the twentieth …